الاجابة النموذجية لاختبار صيدلي
Q01. ACE mechanism is:
• Converting Ag II to vasoconstrictor Ag I
• ✓ Converting Ag I to vasoconstrictor Ag II (CORRECT)
• Converting Ag I to vasodilator Ag II
• Converting Ag II to vasoconstrictor Ag I
Q02. Which of the following amino acids is an inhibitory transmitter and increases the membrane permeability to chloride ions, causing IPSP in the CNS?
• ✓ Glycine (CORRECT)
• Glutamate
• Aspartate
• Alanine
Q03. Which of the following drugs can cause rickets in children by interfering with Vitamin D action?
• Tetracycline
• Phenylbutazone
• ✓ Phenytoin (CORRECT)
• Ciprofloxacin
Q04. Which of the following statements is true regarding cholestyramine?
• It inhibits free fatty acid release from adipose tissue
• It releases lipoprotein lipase
• It blocks the final step in the synthesis of cholesterol in the body
• ✓ When used in large doses, it decreases serum cholesterol (CORRECT)
Q05. The renal clearance of inulin is used as a measurement of:
• Effective renal blood flow
• Rate of renal drug excretion
• Intrinsic enzyme activity
• ✓ Glomerular filtration rate (GFR) (CORRECT)
Q06. Which of the following insulins has the shortest duration of action?
• Isophane insulin
• ✓ Soluble insulin (CORRECT)
• Insulin zinc suspension
• Protamine zinc insulin
Q07. Condition in which cardiac output is less than body need:
• Angina
• Arrhythmia
• Gout
• ✓ C.H.F (CORRECT)
Q08. Which of these statins is safe to consume with grapefruit juice?
• ✓ Rosuvastatin (CORRECT)
• Atorvastatin
• Simvastatin
• Lovastatin
Q09. Which of the following cytochrome P450 isoenzymes is involved in the metabolism of a large number of drugs in human beings and has been implicated in major drug interactions?
• ✓ CYP 3A4 (CORRECT)
• CYP 2C9
• CYP 2E1
• CYP 1A2
Q10. What is true in relation to drug receptors?
• All drugs act through specific receptors
• All drug receptors are located on the surface of the target cells
• ✓ Agonists induce a conformational change in the receptor (CORRECT)
• Partial agonists have low affinity for the receptor
Q11. Immunosuppressive effect of glucocorticoids is caused by:
• ✓ Reducing concentration of lymphocytes (T and B cells) and inhibiting function of tissue macrophages and other antigen-presenting cells (CORRECT)
• Suppression of cyclooxygenase II expression which results in reducing amount of an enzyme available to produce prostaglandins
• Activation of phospholipase A2 and reducing prostaglandin and leukotriene synthesis
• All of the above
Q12. A patient with chronic obstructive pulmonary disease (COPD) is receiving an orally inhaled muscarinic receptor-blocking drug to maintain bronchodilation. What drug belongs to that class?
• Albuterol
• Mometasone
• ✓ Ipratropium (CORRECT)
• Beclomethasone
Q13. NSAIDs increase the risk of CNS adverse effects (e.g., seizures) when taken with which group of antibiotics?
• Macrolides
• Penicillins
• Aminoglycosides
• ✓ Quinolones (CORRECT)
Q14. Which is NOT the characteristic feature of alkaloid?
• Complex molecular structure and nitrogen in the molecule
• Basic in nature
• Biosynthetically derived
• ✓ Acidic in nature only (CORRECT)
Q15. Anticoagulation is needed immediately in a patient with pulmonary embolism since there is some concern about a possible drug-induced thrombocytopenia, the most appropriate drug for parenteral administration in this patient is:
• Clopidogrel
• Enoxaparin
• ✓ Heparin (CORRECT)
• Ticlopidine